The longevity and physical benefits of Human Growth Hormone (HGH) have been documented for years. These benefits include, increased longevity, reduced aging, improved skin elasticity, increase muscle mass, improved energy, increased libido, and increased quality of life. In the past HGH has only been reserved for children with Growth Hormone (GH) deficiency or for rare cases of adult onset Growth Hormone Deficiency.
The reasons GH has become widely accepted is because of the potential side effects. Growth Hormone when given exogenously is not controlled by normal feedback mechanisms, therefore tissue exposure to elevated concentrations is persistent and eventually may lead to side effects or tachyphylaxis (reduced efficacy). Also because the body cannot modulate tissue exposure to exogenous GH, which means the practitioner prescribing GH would have to guess what the dose should be. The best analogy I can come up with is giving exogenous Human Growth Hormone is like continuously putting your foot on the gas pedal. This produces benefits but potentially can cause side effects as well. This is the reason HGH replacement hasn’t become mainstream, until now (read on)
Over the last decade in the anti-aging world there has been extensive research on how to safely and effectively increase growth hormone levels. New pharmaceutical agents include the secretagogues (sermorelin, GHRP-2, GHRP-6). Secretagogues are proteins that are given which stimulate Growth Hormone release.
Why are secretagogues safer?
- Effects are regulated by negative feedback involving the inhibitory neurohormone, somatostatin, so that unlike administration of exogenous GH administration, overdoses of endogenous hGH are difficult if not impossible to achieve.
- Because of the interactive effects of sermorelin and somatostatin, release of hGH by the pituitary is episodic or intermittent rather than constant as with injected rhGH
- Tachyphylaxis is avoided because sermorelin/GHRP-2 release of GH from the pituitary is not constant, it is cyclical like the body intended. But the overall effect still favors increase in total GH release.
- Sermorelin/GHRP-2 stimulates pituitary gene transcription of GH messenger RNA, increasing pituitary reserve and thereby preserving more of the growth hormone neuroendocrine axis, which is the first to fail during the aging process.
What does all this mean?
- Exogenous GH administration produces positive results but is hard to monitor and hard to dose, which can lead to side effects. A new approach to anti-aging and longevity is needed.
- Secretagogues (Sermorelin, GHRP-2), work by increasing endogenous growth hormone from the pituitary producing all the benefits one would expect.
- Secretagogues, are easy to dose without side effects, because the GH that is produced functions and acts like normal GH and can have feedback inhibition if needed.
- Secretagogues increase pituitary GH messenger RNA which protects pituitary reserve and protects the GH neural axis as we age.
Research has shown that growth hormone (secretagogue) therapy can produce the following results:
- Skin—Increased elasticity, texture, and tightness, particularly in the face.
- Energy—Increased energy and emotional stability.
- Bone—Improved bone strength and mass.
- Libido—Increased sex drive.
- Muscle—Increased muscle strength and mass.
- Fat—Decreased body fat, particularly in the abdomen.
- Healing—Shorter recovery time from injuries and exercise.
- Memory—Enhanced brain function and growth of neuron dendrites.
- Heart—Improved cardiovascular strength and lowered blood pressure.
- Kidney—Improved kidney function.
- Immune System—Improved immunity and healing.
- Hair—Improved hair texture.
- Cholesterol—Elevated HDL (good cholesterol) and lowered LDL (bad cholesterol).
- Mental Health—Increased emotional stability and sense of wellbeing.
- Metabolism—Increased metabolism and greater ability to control weight.
- Stress—Increased protection from the ravages of stress and cortisol.
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