LOW DOSE NALTREXONE (LDN)
Naltrexone has been commonly used at daily doses of 50-300mg since it was first licensed in 1984. Naltrexone has been used in lower doses to treat multiple diseases since 1988 and is considered “standard dose” when given in daily amounts of 50mg or more.
Naltrexone acts primarily by blocking opiate receptors and therefore is used mainly for addiction or opioid overdoses.
When used in low doses (less than 10 mg daily), it is now widely understood to act as an Immunomodulator. An Immunomodulator modifies the immune response or the functioning of the immune system. Many studies have shown efficacy for a number of medical conditions.
How Does LDN Work?
Naltrexone, when used in a lower dose can modulate the immune system helping with chronic inflammation, decrease pain, and have anti-tumor effects.
Blocking the Opiate Receptors for a short period of time leads to:
- More endogenous opiate-like molecules to be made and released naturally by the body (these are called endorphins and enkephalins).
- Once LDN degrades from the receptor site, there is an increased endorphin and enkephalins sensitivity to the existing receptors.
- More Opiate receptors are formed to capture endorphins and enkephalins.
Benefits of LDN:
• Whole-body anti-inflammatory effect
• Decrease in Pain
• Improvement in Mood
• Improvement in Energy
• Stimulating mucosal and tissue healing.
• Directly inhibiting tumor growth
• Reducing death of neurons
What diseases are currently being treated with Low Dose Naltrexone?
- Hashimoto’s or Autoimmune Thyroiditis
- Multiple Sclerosis
- Chronic Fatigue
- Chronic Pain
- Complex Regional Pain Syndrome
- Crohn’s Disease
- Ulcerative Colitis
- Autoimmune Disease
Dosing of LDN is not standard and a consultation with a physician is required to obtain a prescription.